Saccharomyces Boulardii Probiotic


  • Saccharomyces Boulardii Can normalizes, protect, improve and keep intestinal gut flora Work Well.
  • Best Time to Take it: Before Bed.
  • Best Dose: 250 mg is the common dose. Different gastrointestinal disorders may vary.
  • 4 Ways to Take it: Swallow the whole Capsule or Sprinkle the Contents onto Different Foods or Drinks.
  • Few Side Effects Like Bloating, Flatulence, and Constipation. 

As we known, intestinal microbiota plays an important role in the health and function of the gastrointestinal tract. Have you ever heard that as soon as we are born, microorganisms begin to colonize the gut and the gut microbiota is formed? It's very surprising!

healthy gut

About Intestinal Probiotics

It's frustrating that the gut environment is very fragile. It will be changed as our habits or stress. Probiotics are healthy microorganisms that can alter the gut flora balance.

It contains different micro-organisms such as yeast (Saccharomyces Boulardii) and bacteria (lactobacillus, bifidobacterium). Micro-organisms (flora) are naturally found in the stomach/intestines/vagina. Some conditions (such as antibiotic use, travel) can change the normal balance of bacteria/yeast.

Differences Between Yeast & Bacteria Probiotics

We will introduce Saccharomyces Boulardii Probiotic (S. boulardii) - the Only Yeast among all Probiotics. It’s known as “friendly bacteria”: Natural and Non-pathogenic yeast.

Saccharomyces Boulardii can prevent the growth of harmful bacteria in the stomach and intestines to maintain and restore the healthy ecology of the small and large intestines. 

 Intestinal Probiotics

Where is S. Boulardii Found?

Probiotics are widely present in daily foods such as yogurt, juices and soy beverages. It also exists in dietary supplements. How about S. Boulardii? Where is it from?

Scientists find that not only can S. boulardii Probiotic be derived from lychee, mangosteen fruit, and kombucha but it is also derived from dairy products such as kefir. Wow! It’s amazing that fruits like lychee can be extracted S. boulardii.


Benefits of Saccharomyces Boulardii

It’s certain that yeast is much better than bacteria. As the only intestinal yeast probiotics, what benefits does S. boulardii bring to us?

gastrointestinal disorders

In a 2010 systematic review and meta-analysis of 31 randomized, placebo-controlled treatment arms in 27 trials (encompassing 5029 adult study patients), S. Boulardii was found to be significantly efficacious and safe in 84% of those treatment arms and has been used safely in infants and children as well.

Except this study, scientists have do researches and applications on Saccharomyces Boulardii for more than 50 years. It’s proved positive effective on gut health:

  • Helps to maintain the balance of good microorganisms in the gut.
  • Keeps the gut functioning well.
  • Normalizes the intestinal gut flora.
  • Protects good microorganisms in the gut.
  • Improves consistency of bowel movements.


Helpful for Traveler's Diarrhea

Have you ever heard of Traveler's Diarrhea(TD)? It often occurs three or more loose stools within 24 hours when we are in travel. This is a bad experience of travelling.

We found a 2019 review of 18 clinical trials published in the peer-reviewed journal indicated that Saccharomyces Boulardii showed a significant reduction in traveler's diarrhea incidents.

So next time when traveling, you can take Saccharomyces Boulardii 250 mg Capsule dietary supplement. Pertect experience!

Traveler's Diarrhea(TD)


 Helpful for Helicobacter pylori

What's more, S. Boulardii is also helpful to Helicobacter pylori. You see, like an uninvited group of rowdy party crashers, H. pylori can punch holes through walls, specifically holes in the stomach or small intestinal lining.

And this damage can cause ulcers and diarrhea among other issues. The Study from UCLA scientists showed that Saccharomyces Boulardii may decrease the risk of diarrhea when given at the same time to patients receiving medication for H. pylori.[1]

healthy gut

Saccharomyces Boulardii and Antibiotics

Most people may concern whether Antibiotics may prevent Saccharomyces Boulardii Probiotic from working well like other probiotics. It's good news that due to its natural fungal properties, S. boulardii probiotics do not need to be taken separately from antibiotics because they are intrinsically resistant to antibiotics.[2]


Best Time to Take Saccharomyces Boulardii

Saccharomyces Boulardii 250 mg Capsule is the common dose. We'd better take it before bed. Why?

Because: the gut is pretty inactive at night. If you think about it, you don’t usually wake up in the middle of the night to poop. If you ingest a probiotic at night when your bowel isn’t moving, there’s a better chance that it will hang around, divide, and potentially get integrated into your gut.

This sounds really reasonable. Isn't it?

Saccharomyces Boulardii 250 mg Capsule Misspep

How to Take Saccharomyces Boulardii

When we take it at night, there are 4 ways to take it.

One way is to swallow the whole capsule directly with water or drink.

The Other 3 ways are below. Open the capsule and sprinkle the contents:

  • Directly onto your tongue then rink at least 4 ounces of water or juice;
  • Sprinkle over semisolid food like applesauce, please swallow right away without chewing;
  • Dissolve contents in liquid and drink like juice.


How Much Saccharomyces Boulardii Should I Take

Saccharomyces Boulardii is helpful for different gastrointestinal disorders. According to clinical trials, in different circumstances, we should take the dose as follows:

Traveler’s Diarrhea: Doses of 250, 500, or 1000 milligrams (mg) capsules taken by mouth per day for three weeks in adults.[3]

Antibiotic-Associated Diarrhea: Not less than 250 mg (5 billion CFU) but not more than 500 mg (10 billion CFU) in children and not more than 1000 mg (20 billion CFU) in adults.[4]

Irritable Bowel Syndrome: An S. boulardii dose of 9 billion CFU taken by mouth per day was used for four weeks in adults with IBS.[3]

Crohn’s disease: For adults with Crohn’s disease, an S. boulardii dose of 500 milligrams (mg), two capsules taken by mouth per day for up to six months, was used in addition to maintenance therapy with mesalamine.[5]

Ulcerative colitis: For adults with ulcerative colitis, 250 milligrams (mg) of S. boulardii was taken by mouth three times a day for four weeks during maintenance treatment with mesalamine.

leaky gur syndrome

Pease note that if you are allergic to yeast, you shouldn’t take S. Boulardii. For older adults, they should also avoid using S. boulardii due to the increased risk of fungal infection.

If you are weak in immune system, you'd better consult a doctor or pharmacist before taking it.

Maybe one day, you forgot to take it timely. Just skip it. Take your next dose at the regular time. Please remind that do not use extra Saccharomyces Boulardii to make up for the missed dose.


How to Storage it

Saccharomyces Boulardii is one of yeasts and yeasts are belong to fungus. They are fond of wet and low temperature environment.

It should be storaged away from moisture and heat. Saccharomyces Boulardii can be in either the lyophilized (freeze-dried) or heat-dried forms.

Heat-dried products, which lose their potency rapidly, should be refrigerated after opening. Conversely, freeze-dried products of S. boulardii are stable at room temperature, provided they are protected from moisture. We should follow the directions on the product label.


Saccharomyces Boulardii Probiotic Side Effects

Every coin has two sides. It’s the same to Saccharomyces Boulardii Probiotic. It's well-tolerated, but common side effects include bloating, flatulence, and constipation.

Maybe this is not a complete list of side effects. But Saccharomyces Boulardii is thought to be likely safe for most people when used as directed for up to 15 months. If you have any signs above, please stop taking it and consult your doctor.


The Bottom Line

In this article, we have discussed the existence, benefits, best time and doses to take, side effects and storage of Saccharomyces Boulardii.

We’d better take it before bed because S. Boulardii can get integrated into your gut perfectly. As the only yeast of probiotics, it has few side effects to our gut and is resistant to antibiotics.

Saccharomyces Boulardii can keep our gut work well. We should take right dose as mentioned earlier for different gastrointestinal disorders. You will have a stronger gut. Try Saccharomyces Boulardii 250 mg capsules now!



Q: Can you have saccharomyce boulardii supplements on a daily basis?

A: I don't think anybody knows the long-term consequences, if any, of doing so. This yeast is thought to be non-pathogenic and to stay within the gut, so you're probably okay taking it daily.


Q: Anyone try saccharomyces boulardii?

A: Yes, I use it and love it. I must say it really helps with my digestive issues, especially bloating and diarrhea. I generally take it only once a week not every day. It's enough for me.


Q: What is best time to take probiotics capsule before or after meal? Or empty stomach? 

A: We’d better take it before bed because S. Boulardii can get integrated into your gut perfectly.


Q: Does it help for crohn's disease....I have real mushy stools and not a normal bowel movement.

A: Certainly. For adults with Crohn’s disease, two capsules taken by mouth per day for up to six months, was used in addition to maintenance therapy with mesalamine.


[1] Kaźmierczak-Siedlecka K, Ruszkowski J, Fic M, Folwarski M, Makarewicz W. Saccharomyces boulardii CNCM I-745: A Non-bacterial Microorganism Used as Probiotic Agent in Supporting Treatment of Selected Diseases. Curr Microbiol. 2020;77(9):1987-1996. doi:10.1007/s00284-020-02053-9

[2] Williams NT. Probiotics. Am J Health Syst Pharm. 2010;67(6):449-458. doi:10.2146/ajhp090168

[3] McFarland LV. Systematic review and meta-analysis of Saccharomyces boulardii in adult patients. World J Gastroenterol. 2010;16(18):2202-2222. doi:10.3748/wjg.v16.i18.2202

[4] Szajewska H, Kołodziej M. Systematic review with meta-analysis: Saccharomyces boulardii in the prevention of antibiotic-associated diarrhoea. Aliment Pharmacol Ther. 2015;42(7):793-801. doi:10.1111/apt.13344

[5] Sivananthan K, Petersen AM. Review of Saccharomyces boulardii as a treatment option in IBD. Immunopharmacol Immunotoxicol. 2018;40(6):465-475. doi:10.1080/08923973.2018.1469143

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