All You Are Wondering About NMN?


NMN Chemical Structure 

(Figure1. Chemical Structure of NMN)

Nicotinamide Mononucleotide, called for short NMN, is a Vitamin B3 (niacin) derivative. On the molecular level, it's a nucleotide made up of a nitrogenous base (nicotinamide), a sugar (ribose), and a phosphate group(Figure 1).

NMN is an NAD+ precursor that the body uses to restore more youthful levels of NAD+. Once you take NMN and it gets into your bloodstream, it turns into NAD+. And guess what? This NAD+ stuff is stored in your muscles and vital organs, giving them a real boost!

It's like a secret weapon that helps your body work at its absolute best. So, you can say goodbye to feeling sluggish and hello to peak performance!

Studies about NAD+ Reversing DNA Aging in Mice


NAD Enhances SIRTUIN Genes

Besides stimulating the activity of mitochondria, NAD+ can enhance the activity of SIRTUIN genes that plays a part in maintaining healthy aging.


NAD+ Helps Control DNA Damage

As organisms grow older, they accrue DNA damage due to environmental factors such as radiation, pollution, and imprecise DNA replication. According to the current aging theory, the accumulation of DNA damage is the main cause of aging. Almost all cells contain the ‘molecular machinery’ to repair this damage. This  machinery consumes NAD+ and energy molecules. Therefore, excessive DNA damage can d valuable cellular resources.

One important DNA repair protein, PARP (Poly (ADP-ribose) polymerase), depends on NAD+ to function. Older individuals experience decreased levels of NAD+. The accumulation of DNA damage as a result of the normal aging process leads to increased PARP, which causes decreased NAD+ concentration. This depletion is exacerbated by any further DNA damage in the mitochondria.

A 12-month long study carried out by the University of Washington St Louis showed that oral administration of NMN was quick to action, effectively raising NAD+ levels in minutes. NMN showed a sharp increase in the blood measurement after only 2.5 minutes. It increased NAD+ levels in the liver in just 10 minutes and muscle tissue by 30 minutes.


SIRT1 Genes Function

Sirtuins are a family of seven proteins that play an important role in cellular health. Sirtuins can only function in the presence of NAD+. Supplements like NMN&NR boost NAD to youthful levels which then act as fuel for the sirtuin gene.

Functions of sirtuins:

  • Influence Epigenetics
  • Prevent cancer
  • Improve cardiovascular function
  • Improve metabolism(liver, pancrea, muscle, body fat)
  • Improve neurological function.
  • Reduce inflammation/ stress response.

Leave a comment

Please note: comments must be approved before they are published.